The 36-year-old stormed through 6-1, 6-4 for what was her 16th straight Wimbledon win, having won the title in 2015 and 2016 before taking time off to start a family.
It's been an up and down season for Keys, but she has performed well at the majors - she reached last year's US Open final and this year's French Open semis, both of which she lost to compatriot and friend Sloane Stephens.
John Patrick Fletcher via Getty Images Serena Williams slugs a shot in her victory over Aranxta Rus on Monday at Wimbledon. "She got a little lucky and played well when she needed to".
After Makarova edged out a tight first set, the Dane looked to have recovered by producing the ideal response, taking the second set 6-1. "Is there a spray?" she said.
The ninth-seeded American had struggled in the opening set of her first-round match with Johanna Larsson, but roared back to win.
"I think it is important that, when you want to serve well, your point-for-point mentality is right", Federer said. Federer won the match 6-4, 6-4, 6-1.
Still, on Wednesday, the women of Wimbledon had a conspicuously bright spotlight as they were featured in five of the seven matches held on the two biggest courts.
The Danish second seed struggled in the first set, losing it 6-4, but bounced back to take the game to a decider after winning the second 6-1.
Despite the separation from Nike, Federer is still wearing personalised Nike shoes that include an updated logo just for the 2018 Wimbledon Championships. She produced her best tennis to save three match points when 5-3 and 40-0 behind, and saved another before breaking to level the set. "I told her, "Look, I'm going to stop".
"What I've learned through the experience-everybody is different, every person is different, every physical body is different", she said.
"I don't know. I don't know, " he began, before offering quite a list for someone who doesn't know. "Hopefully, it's just one", she said, laughing.
Dutchwoman Kiki Bertens is also through with a 6-4, 6-0 result against Russian Anna Blinkova, but Poland's Agnieszka Radwanska is out following a 7-5, 6-4 loss to Czech Lucie Safarova.
He said his decision to make six changes to his side was down to fatigue rather than any attempt to play for a draw. The biggest cheers were reserved for yellow cards, adding to the hilarity of the spectacle.
I want to make sure that we continue to secure this country by making smart investments, such as those at our ports of entry. Looking for news you can trust? CBP is limited to the country's entry points and within 100 miles of a US border.
The CIA and Federal Bureau of Investigation made their assessment with "high" confidence, while the NSA's was only "moderate". Warner of Virginia - have both made previous statements supporting the intelligence community's assessment.
Another area that is being watched is a cluster of thunderstorms in between Bermuda and the east coast of the United States. Both systems are expected to strengthen as we enter into the second full month of the 2018 Atlantic hurricane season.
For thousands of families as for Jesus et al, "It is a cage, it's a detention center , its a concentration camp", says the Rev. Carlsen said he does not know how long the display will be outside the church.
The video closes with the Trump University logo. "I am the only person who immediately walked out of my " Ali G " interview". You don't know [expletive]", Trump continues in the clip right before another message appears saying, " Sacha graduates.
There was no mention of the trade tensions in reports on the latest travel advisory posted by the Chinese Embassy in Washington . On Thursday, Commerce Ministry spokesman Gao Feng hit back at "threats and blackmail" ahead of the planned US tariff hike.