Small study suggests ibuprofen alters testosterone metabolism

GettyImages-517243208

While it is important to note that this was a small study and more research is clearly called for, the fact that ibuprofen is so widely and casually used by so many men makes it a point of concern, particularly for those who intend to start a family. The scientist tested aspirin, Tylenol and ibuprofen.

The study involved 31 men (ages 18 to 35) who were randomly assigned to take ibuprofen (two doses of 600 mg each) or a placebo every day for six weeks.

Clinically, this condition is called "compensated hypogonadism"-"hypogonadism" because the body probably isn't producing testosterone at the appropriate rate, and "compensated" because other hormones have kicked in and gotten testosterone levels to increase. "The decrease in the free testosterone/LH ratio resulted primarily from the increased LH levels, revealing that testicular responsiveness to gonadotropins likely declined during the ibuprofen exposure", the authors write.

This condition is prevalent in elderly men and is associated with reproductive and physical disorders.

Luteinizing hormones are secreted by the pituitary gland and stimulate the testicles to produce testosterone.

Researchers told CNN that, while these effects were reversible, they were unsure of whether there were long-term health effects associated with the prolonged use of ibuprofen.

A new study suggests that some men who regularly take the anti-inflammatory drug ibuprofen could be doing serious damage to their testicles, or at least the stuff stored inside them, CNN reported Tuesday. "Based on these data, I personally would be very reluctant to take ibuprofen for longer than the 10 days normally indicated on the packet". After 44 days, levels were even higher.

The new study isn't the first to suggest that ibuprofen has downsides.

As a fun added bonus, previous research has found a link between low testosterone levels and premature death.

The finding comes after repeated warnings from other researchers that ibuprofen can raise the risk of heart attacks in the general population and cause medical problems for pregnant women and their babies, including a more than doubling of the risk of miscarriage.

Compensated hypogonadism can lead to fertility issues, muscle wastage, and erectile dysfunction. But researchers are concerned about long-term use among athletes.

Related:

  • Gwyneth Paltrow confirms engagement to Brad Falchuk

    Gwyneth Paltrow confirms engagement to Brad Falchuk

    Her blog on the drug-laced drinks read: "Ringing in 2018 with a CBD-spiked cocktail intrigued many of us at Goop ". They first went public with their relationship when they attended Robert Downey Jr .'s 50th birthday bash in 2015.
    Japan rejects South Korean call for extra steps over 'comfort women'

    Japan rejects South Korean call for extra steps over 'comfort women'

    South Korean activists estimate there may have been as many as 200,000 Korean women forced to work in the brothels. In 2015, when there were 47, 36 accepted the settlement, a the official said.
    'Our national embarrassment': Donald Trump dragged after stumbling over United States  national anthem

    'Our national embarrassment': Donald Trump dragged after stumbling over United States national anthem

    But as we approach midterm elections and Republicans try to court black voters, Trump may have to tread carefully. There were times when Trump wasn't singing at all and at others he seemed to be speaking out random words.
  • Razer Phone First Smartphone Offering HDR and Dolby 5.1 for Netflix

    Razer Phone First Smartphone Offering HDR and Dolby 5.1 for Netflix

    The triple-headed snake trademark of Razer is one of the most recognized logos in the global gaming and esports communities. But it's a concept that makes a lot of sense, not just for the Razer Phone , but for all sorts of mobile phones.
    Nigeria evacuates 493 citizens from Libya

    Nigeria evacuates 493 citizens from Libya

    He explained that those who were critically ill were taken to University of Port Harcourt Teaching Hospital for treatment. They are mainly youths aged between 19 and 42 years, majority of the returnees are from Edo and Delta states.
    Kendall Jenner Is Proud Of Her Golden Globes Acne!

    Kendall Jenner Is Proud Of Her Golden Globes Acne!

    The runway star wrote in the October 2015 post: 'Where it really impacted me was how self-conscious I became about it. Jenner, who attended the Golden Globes on behalf of Vogue , shared photos of her look on Instagram.
  • Battlegrounds becomes the best-selling PC game of all time

    Battlegrounds becomes the best-selling PC game of all time

    The devs say the replay report tool will be a more effective and efficient way of flagging players who are spoiling your fun. Update 1.0 also works on game performance by offering more stability through various bug fixes and tweaks in performance.
    British PM May to reshuffle cabinet, appoint new ministers

    British PM May to reshuffle cabinet, appoint new ministers

    Britain's Foreign Secretary Boris Johnson has kept his portfolio despite a series of high-profile gaffes. Transport Minister Chris Grayling had been strongly linked with the job before the appointment.
    Jacob Eason plans to leave Georgia, transfer to Washington

    Jacob Eason plans to leave Georgia, transfer to Washington

    The Huskies brought in not one but two four-star quarterbacks in their 2018 recruiting class in Jacob Sirmon and Colson Yankoff. Eason, a sophomore, entered the season as UGA's starting quarterback, but was injured in the opener against Appalachian State.
  • Altice announces separation of US, European businesses

    Altice announces separation of US, European businesses

    Altice is to separate Altice USA from the parent company by spinning off its 67.2% stake in the company. The group's leveraged loans also rebounded strongly in Europe's secondary loan market.
    January 2018 Android Distribution Shows Slight Bump For Oreo

    January 2018 Android Distribution Shows Slight Bump For Oreo

    While KitKat saw a 0.6 percent drop for 13.4 percent to 12.8, Jelly Bean saw a marginal drop from 5.9 percent to 5.6 percent. A further breakdown reveals that Android 8.0 takes a 0.5 percent share and the latest Oreo 8.1 sits at just 0.2 percent.
    Kanye West FaceTimes sick fan

    Kanye West FaceTimes sick fan

    Kanye West reached out to a girl fighting cancer and recently rapped to her before she died. Kanye West made dreams come true for a dying girl by calling her up and rapping to her.

Comments

Other news