AKR1C2 Gene - GeneCards | AK1C2 Protein | AK1C2 Antibody

AKR1C2 Gene - GeneCards | AK1C2 Protein | AK1C2 Antibody

  • This gene encodes a member of the aldo / keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and / or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds to bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. Works in concert with the 5-alpha / 5-beta-steroid [provided by RefSeq, Dec 2011]

Reductases to convert steroid hormones into the 3-alpha / 5-alpha and 3-alpha / 5-beta-tetrahydrosteroids. (5-alpha-DHT) to 5-alpha-androstane-3-alpha, 17-beta-diol (3-alpha-diol) were used in the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT). You have a high bile-binding ability.

No data available for Tocris Summary, Gene Wiki entry, PharmGKB "VIP" Summary, fRNAdb sequence ontologies and piRNA Summary For AKR1C2 Gene

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