Memory Loss From Alzheimer's Could Be Reversed

The results of a new study could lead to earlier diagnosis of Alzheimer’s and the use of more effective drugs Carlos Osorio  AP

A small clinical trial of 10 patients with early Alzheimer’s disease has shown that the memory loss and cognitive impairment can be reversed.

Not only were improvements sustained, but some patients returned to work, regained their ability to speak different languages, and showed an increase in brain matter volume after just a few months.

The study investigated the effects of a new kind of personalised treatment on the cognitive abilities of 10 patients who were experiencing age-related decline. 

The treatment - called metabolic enhancement for neurodegeneration, or MEND - is based on 36 different factors, including changes in diet, exercise, and sleeping habits, plus the integration of certain drugs, vitamins, and brain stimulation therapy to their regular routine. 

For instance, a 69-year-old professional and entrepreneur, was about to shut down his business after experiencing progressive memory loss over the past 11 years.

A life-long ability to add columns of numbers rapidly in his head returned and he was able to remember his schedule and recognize faces at work. He continued as the participant of the study and after 22 months, he returned for a quantitative neuropsychological testing. He is now expanding his business. The patients went through neuropsychological testing and quantitative MRI's for result analysis and they were administered a well mapped out programmatic and personalized therapy as treatment.

His foreign language ability had also returned. Researchers also reported that after nine months in the programs, the lady presented no longer evidence of cognitive decline.

However, they do mention something that all but one of the patients have in common - they are all at genetic risk for Alzheimer's disease, carrying at least one copy of the APOE4 allele.

'We're entering a new era, ' said Dr. Bresden. Former medical techniques avoided testing for APOE because it was thought that even if discovered, there was nothing to do to counteract it.

The findings of the study are good news for everyone, but Bredesen revealed that the result should be followed by another more extensive study. "Imagine having a roof with 36 holes in it, and your drug patched one hole very well-the drug may have worked, a single "hole' may have been fixed, but you still have 35 other leaks, and so the underlying process may not be affected much", Bredesen said". "We think addressing multiple targets within the molecular network may be additive, or even synergistic, and that such a combinatorial approach may enhance drug candidate performance, as well", Bredesen says. Because so many families and individuals are impacted, the Alzheimer's Association - Greater Michigan Chapter - which is headquartered in Southfield - encourages people engage in dialogue to help spread awareness by tweeting and posting stories and thoughts using the #puremipurple hashtag on Twitter, Facebook and Instagram.

These really are some fantastic results in the world of healthcare, and studies are due to continue on a larger scale.

Cognitive decline is often listed as the major concern of older adults.

"Around 5 million Americans suffer from Alzheimer's disease, which slowly attacks cognition, robbing patients of a lifetime of memories". Without effective prevention and treatment, the prospects for the future are bleak.

For millions and millions of patients and caregivers, organizations such as the Alzheimer's Association and Alzheimer's Foundation of America are founts of information for the who, what, when, where, how and why questions about Alzheimer's, which does not discriminate.

An Alzheimer's Disease diagnosis might just be about the scariest news anyone could fear to hear from the doctor, but the fact is that those fearful diagnoses are on the increase in the United States. As of today, there is no cure for Alzheimer's Disease. Please see paper for the complete list. The Senate Labor-HHS Appropriations Subcommittee announced a proposed $400 million increase for Alzheimer's research at the National Institute of Health. Based in Novato, CA, The Buck is dedicated to extending "Healthspan", the healthy years of human life and does so utilizing a unique interdisciplinary approach involving laboratories studying the mechanisms of aging and those focused on specific diseases.

A report published in NewsMax revealed, "A highly-personalized combination treatment program reversed Alzheimer's disease symptoms in patients, according to researchers".




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